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Biotechnology

University

Introduction to the Biotechnology Degree. Source: Wikipedia (CC BY-SA 4.0).

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Definition, foundations, and applications of biotechnology

  • Biotechnology: the application of biological systems to create or modify products/processes.
  • Key difference: Biotechnology does not necessarily require genetic modification (unlike genetic engineering).
  • Scientific foundations: Biology, engineering, physics, chemistry, and biomedicine.
  • Origin of the term: Probably coined by Károly Ereki in 1919.
  • Modern biotechnology (Cartagena Protocol): Includes in vitro nucleic acid techniques and cell fusion beyond taxonomic families.
  • Scientific risk: Possibility of non-reproducible random results in gene modification.
  • Plant biotechnology: Use of plants for non-food products (biofuels, biodegradable plastics).
  • Bioremediation: Biotechnological use for cleaning contaminated sites and waste treatment.
  • Red biotechnology: Specific applications in medical processes and pharmaceuticals.
  • Molecular diagnostics: Use of PCR, hybridization, and sequencing for rapid and automatable diagnostics.

Applications of biotechnology in health, industry, and the environment

  • Molecular pathology: diagnosis by genetic and biochemical alterations
  • Molecular pathology: immunohistochemistry techniques and genetic analysis
  • White biotechnology: industrial processes, enzymes, and biodegradable products
  • Green biotechnology: food security, resistant crops, and transgenic plants
  • Bt maize: example of pesticide expression through genetic engineering
  • Mycorrhizal fungi: improve forest resistance and adaptability
  • Yellow biotechnology: fermentative processes and food quality improvement
  • Blue biotechnology: marine applications and aquatic ecosystem preservation
  • Grey biotechnology: bioremediation and pollutant removal
  • Bioremediation techniques: phytoremediation, bioventing, bioleaching, rhizofiltration, bioaugmentation, and bioreactors
  • Biosafety risk: horizontal gene transfer in modified organisms

Bioremediation and Biotechnology Classification

  • Bioremediation: use of microorganisms to clean contaminated sites
  • Metagenomics and functional genomics: allow for the understanding of metabolic networks and degradation pathways
  • Hydrocarbonoclastic bacteria (HCB): microorganisms that degrade hydrocarbons in the ocean
  • Specific oil-degrading microorganisms: Pseudomonas, Flavobacterium, Arthrobacter, and Azotobacter
  • Exxon Valdez case (1989): first large-scale success of bioremediation through nitrogen and phosphorus supplementation
  • Final products of biological degradation: carbon dioxide, water, and biomass
  • Limitations of bioremediation: nutrients, clays, aeration, pollutant availability, and age of contamination
  • Composting technology in biopiles: applied to sludge and drill cuttings
  • Bioplastics: an alternative to PET to reduce degradation times
  • Orange biotechnology: educational focus, dissemination, and training for society
  • Golden biotechnology: includes bioinformatics (big data) and nanobiotechnology (nanoscale)
  • Purple/Violet biotechnology: legal aspects, patents, bioethics, and bioterrorism safety protocols

Biological engineering and biotechnology: fundamentals, applications, and risks

  • Bioengineering: integration of biological sciences with classical engineering (chemistry, computer science, etc.)
  • Bioengineering objective: scaling laboratory biological processes to industrial production
  • Bioengineering requires knowledge in management, economics, and regulation (patents, FDA)
  • Bioinformatics: use of computer techniques to organize large-scale molecular information
  • Key areas of bioinformatics: functional genomics, structural genomics, and proteomics
  • GMO advantage: higher yield, reduction in pesticides, and nutritional improvement
  • Cross-pollination risk: transfer of resistance genes to non-GM crops
  • Insecticide risk: development of resistance in insects and damage to non-target species
  • Biodiversity risk: displacement of traditional crops by GM crops
  • Health risk: transfer of toxins/allergens and escape of modified agents
  • Group 1 Agent: unlikely to cause disease
  • Group 2 Agent: causes disease, occupational hazard, low transmission, has treatment
  • Group 3 Agent: high probability of transmission, no effective treatment or prophylaxis

Impacts of mechanization and the biosafety regulatory framework in Mexico

  • Mechanization: generates unemployment and rural exodus
  • Technological requirements: money, land, and water
  • SS and SAGARPA: regulate human health, plant health, and animal health
  • SEMARNAT: regulates environmental impact and ecological equilibrium
  • SHCP: regulates customs, taxes, and cross-border movements
  • Secretaría de Economía: responsible for foreign trade and treaties
  • IMPI: manages patents and trademarks (industrial property)
  • SEP and SECITHI: linked by education and research policies
  • Cartagena Protocol: ratified by Mexico on April 30, 2002
  • Cartagena Protocol: entered into force on September 11, 2003
  • Art. 420 Ter Federal Penal Code: handling transgenic organisms can be a crime
  • ILBOGMs: initiative requested by the Senate from the AMC in 2002

Flashcard preview (6 of 25)

  1. 01

    Etymology of the term 'biotechnology': what do its Greek roots mean?

    βίος (life), τέχνη (skill/craft), and -logía (treatise, study, science).

  2. 02

    According to the OECD, what principles apply to the treatment of organic and inorganic materials by biological systems?

    Principles of mathematics and engineering.

  3. 03

    According to the Cartagena Protocol, which in vitro nucleic acid technique includes recombinant DNA?

    In vitro nucleic acid techniques.

  4. 04

    In biotechnology, what is the specific term for the use of plants?

    Plant biotechnology.

  5. 05

    Red biotechnology: in what type of medical processes is it applied?

    Medical processes (e.g., antibiotics, vaccines, pharmaceuticals, molecular diagnostics).

  6. 06

    In molecular pathology, what is the basis for cancer diagnosis compared to classical pathological anatomy?

    Its pathogenic characteristics (genetic and biochemical alterations).

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